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Glioblastoma (GBM). GBM is the most Christmas Tree Unicorn Ugly Christmas Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

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Mental Aspects: Another part of why NFL runner-ups don’t make it back to playoffs clearly seems to be mental, however, and it’s hard to say how the Falcons will cope with getting that close to the championship and having it slip through their fingers, especially in such a Christmas Tree Unicorn Ugly Christmas Sweater fashion. There are players like second-year LB Vic Beasley (who had 0 tackles, and could have intercepted the Pats in OT to stop their game-ending drive, but only got one hand on the football and tipped it away) who will no doubt have some negativity and frustration—both external and internal—to deal with after this game. There’s also a new Offensive Coordinator, as Kyle Shanahan has left to take the head coaching job in San Francisco. It usually takes a couple of years for a new OC to really get the freedom and familiarity with his players to institute major changes, so we can expect the Falcons O to look very similar to this season’s, with perhaps a couple of Christmas Tree Unicorn Ugly Christmas Sweater installed by new OC Steve Sarkisian. No one rocks the boat too hard first year, however, so not too much should change.

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“In economics, income = consumption + savings. The income an indivual, or a country, produces is either consumed and/or saved. If you , or a Christmas Tree Unicorn Ugly Christmas Sweater, overspends, you or the country dips into savings or creates debt.” I think this answer is true for the firm or the individual but in the whole economy it is no longer true. In the macroeconomy, everytime some person or entity doesn’t spend, some other person or entity has their income reduced by the same amount. And because that person won’t get their hands on that money, they will not have it to spend further, so the next would-be recipient of that spending doesn’t get that income, which they in turn will not be able to spend….. and so on