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Glioblastoma (GBM). GBM is the most Merry Merry Merry Grinchmas Christmas Ugly Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

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In terms of skills it depends what position they are moving from and to, but I think a season of training with a pro side and some regional amateur rugby games in the lower leagues followed by 1-2 seasons playing below the top flight would be required, if they had the right attributes to reach the top flight. It could be 2 years in total for a winger, or 4 for a more involved position with higher technical and tactical requirements. A player with exceptional physical attributes like being able to run a sub-11 second 100m at 275lbs and a lethal side-step or being fit at 300lbs and immensely strong and Merry Merry Merry Grinchmas Christmas Ugly Sweater explosive might make it earlier as their attacking threat with the ball in hand would do more to cancel out their shortcomings than a more physcially average player.

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People strung cranberries and popcorn, starched little crocheted stars to hang, made paper chains and Merry Merry Merry Grinchmas Christmas Ugly Sweater had glass ornaments, usually from Germany, about two inches wide, they would get old and lose their shine. There was real metal tinsel too, that you could throw on with the argument about single strands and clumps. Each side had it’s followers. In the fifties various lights were a big deal, with bubble lights, that had bubbles in the candle portion that moved when plugged in. There were big primary colored lights strung around the tree too, nothing small or ‘tasteful’ Christmas trees were meant to be an explosion of color and light. I took Styrofoam balls and a type of ribbon that would stick to itself when wet, and wrapped the balls, and then used pins to attach sequins and pearls for a pretty design in the sixties. I also cut ‘pop-it’ beads meant for a necklace into dangling ornaments with a hook at the top to put it on the tree. Wrapped cut-up toilet paper tubes in bright wools too. Kids still remember making those.