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Glioblastoma (GBM). GBM is the most Move Im Gay Ugly Christmas Sweater and most aggressive brain cancer. It’s highly invasive, which makes complete surgical removal impossible. And because of the blood-brain barrier (BBB), it doesn’t respond to any chemotherapy. The standard-of-care entails multiple rounds of surgery and radiotherapy, yet the five year survival is lower than 5%. Pancreatic cancer (PDAC). PDAC is a notoriously stubborn cancer. The only effective treatment is a very painful and very complex operation called “the Whipple procedure”. However, only 20% of patients are eligible for such operation. And even for those lucky patients, only 20% survived more than five years. For the rest majority of patients, the chance of survival is negligible, because PDAC hardly responds to any form of chemotherapy or radiotherapy. The five year survival overall is 6%.

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Who was the worst coach in NFL history? When discussing the worst coaches in NFL history, assuming you’re only referring to head coaching duties, names like Rod Marinelli, Dave Shula, Lou Holtz, and Lane Kiffin are often bandied about, amongst others. These characters represent two major categories of Move Im Gay Ugly Christmas Sweater professional coaching careers; the highly-regarded NFL assistant who couldn’t hack it as a head coach (Gus Bradley, Kevin Gilbride, etc.), and the successful college coach who was unable to transition into coaching multimillionaires (Spurrier, Saban, et al.). In defense of the first four coaches mentioned above, all of them inherited horrible teams. But a few coaches have taken on decently successful franchises, yet completely failed during their fleeting NFL careers.

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In the United States, state capitals aren’t generally the Move Im Gay Ugly Christmas Sweater or most populated cities. Take as an example California (Sacramento is the capital, not Los Angeles or San Francisco) or Illinois (Springfield is the capital, not Chicago) and you could go on with Texas, Florida, etc… even when it comes to the United States as a whole you would think New York City or Los Angeles should be the capital and not Washington D.C, but it goes deeper than that, the United States is not centralized in one city like it happens to France/Paris, UK/London, Germany/Berlin and so on. As to why New York City is considered the capital of the world, it has been called that for the past 60 years. It is the home of the United Nations, Wall Street, New York Stock Exchange, lots of billionaires, people from all over the world live in the city. It’s basically the financial powerhouse of the world although London has been following closely for the past few years. Other reasons to consider New York the capital of world would be fashion, music, entertainment, tourism, etc.